abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly Toxic and Stable Off-pathway Oligomerization of Islet Amyloid Polypeptide Mediated by Cu(II)

등록일
2016년 9월 1일 17시 16분 36초
접수번호
2494
발표코드
PHYS2-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 25분
발표형식
심포지엄
발표분야
물리화학 - Physical Chemistry of Biomolecules and Cells
저자 및
공동저자
김준곤
고려대학교 화학과, Korea
Human islet amyloid polypeptide (hIAPP) is an amyloidogenic protein associated with the pathogenesis of type II diabetes mellitus (T2DM). The toxicity of hIAPP amyloidosis is suggested to be due to oligomeric intermediates rather than insoluble fibrils; however, structural information about these oliogmers is quite limited and therefore elucidation of the structure-toxicity relationship of hIAPP remains elusive. In this presentation, a direct observation of the toxic oligomers of hIAPP, produced through a newly discovered Cu(II)-mediated off-pathway aggregation process, is discussed as well as structural data obtained from various biophysical methods in conjunction with theoretical modeling. The Cu(II)-triggered assemblies of hIAPP oligomers show a highly symmetric flattened cylinder shape, formed via isotraopic aggregations, and display noticeable toxicity toward pancreatic beta-cells. Overall, our studies demonstrate an off-pathway aggregation process for the formation of toxic hIAPP oligomers, which will provide a foundation for developing therapeutic strategies against T2DM.

상단으로