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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Virus based novel Colorimetric Sensor for Cancer Cell Detection

등록일
2016년 9월 7일 14시 05분 46초
접수번호
2522
발표코드
ANAL2-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 14시 : 40분
발표형식
심포지엄
발표분야
분석화학 - Recent Trends in Analytical Chemistry Ⅱ: Analytical Chemistry in Microsystems
저자 및
공동저자
오진우
부산대학교 나노소재공학과, Korea
Color sensor like pregnancy test kit or litmus paper for pH test relies on color change depending on various chemical and physical conditions. Recently, we developed the novel colorimetric sensor which is functionalized with M-13 bacteriophage-based structure color [1], and it could detect TNT down to 300 p.p.b. over similarly structure chemicals [2]. Cancer cells release abnormal gas composition compared with that of normal cells. Therefore, cancer can be diagnosed by breath testing for a unique composition of volatile gas produced by each species of cells. Here, we developed the novel cancer recognition sensor suing virus-based structural color matrix. Due to its liquid crystalline behavior and surface modification ability, M-13 bacteriophage based color sensor exhibited remarkable selectivity and sensitivity to target samples including chemicals which compose VOCs of NCI. Upon exposure of small amounts of target molecules, the resulting colored matrices exhibited distinct different color changes that can be applied to effectively discriminate the target. Although the cancer cell sensing system was used as proof-of-concept in this study, this approach can be generalized to the detection of many harmful and biological toxicants.

References
[1] W.-J. Chung, J.-W. Oh et al. Nature 478, 364 (2011).
[2] J.-W. Oh et al. Nature Comm. 5, 3043 (2014)

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