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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Hyperpolarized Silicon Nanoparticles as Biocompatible Contrast Agents for 29Si Magnetic Resonance Imaging

등록일
2016년 8월 23일 21시 05분 31초
접수번호
3012
발표코드
ANAL1.O-18 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 38분
발표형식
구두발표
발표분야
분석화학 - Oral Presentation of Young Analytical Chemists Ⅰ
저자 및
공동저자
서형림, 최익장, 고혜지, 공경현, 박희정1, 정회일2, 이영복*
한양대학교 응용화학과, Korea
1한국기초과학지원연구원 서울서부센터, Korea
2한양대학교 화학과, Korea
Silicon-based nanoparticles have been attracting a lot of interest in the field of biomedical applications due to their biocompatibility and biodegradability in vivo, as well as their flexible surface chemistry. Here, we demonstrate two different synthetic approaches in order to yield various nano-sized silicon nanoparticles (Si NPs) ranging from 5 nm to 500 nm as hyperpolarized contrast agents for magnetic resonance imaging (MRI). i) The particles were synthesized by means of a chemical reduction of micelles formed by mixing silicon tetrachloride and alkyltrichlorosilane. ii) Magnesiothermic reduction of silica was also processed to produce Si NPs. The Si NPs have many great benefits to the hyperpolarized MR imaging. Since a core region of the crystalline Si NPs is mostly protected from a main relaxation source, such as paramagnetic centers existing at surface defect sites, the Si NPs show extremely long depolarization times (usually longer than 30 mins), resulting in high MR image contrast with minimum or no background signals. In addition, paramagnetic centers on the surface defect sites play a pivotal role in generating MR signal enhancement induced by dynamic nuclear polarization (DNP) mechanism, thereby not necessary to add external radical sources. In conclusion, these features and benefits convincingly suggest that the Si NPs can potentially be used as a biocompatible, targetable, and hyperpolarized MRI contrast agents.

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