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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Enantioseparation of acidic chiral compounds on a clarithromycin- zirconia hybrid monolith by capillary electrochromatography

등록일
2016년 8월 23일 15시 55분 21초
접수번호
3101
발표코드
ANAL2.O-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 00분
발표형식
구두발표
발표분야
분석화학 - Oral Presentation of Young Analytical Chemists Ⅱ
저자 및
공동저자
김미연, 박정학*
영남대학교 화학과, Korea
A weak anion exchanger chiral selector, clarithromycin-incorporated zirconia hybrid monolithic (CLA-ZHM) capillary column was prepared by sol-gel technology. A sol solution consisting of 5.5 mM of polyethylene glycol, 1 mM of water, 3 mM of acetic acid, 2 mM of formamide, and 0.04/0.96 ratio of CLA-TEOSPC/Zr-Bu resulted in a homogeneous monolith having well defined through-pores and tightly anchored to the capillary wall. The CLA-ZHM column was employed for capillary electrochromatographic enantioseparation of ten acidic chiral drugs in mobile phases consisting of acetonitrile (ACN), methanol (MeOH) and triethylamine (TEA)-acetic acid (AcOH) buffer. Effects of ACN/MeOH ratio, AcOH/TEA ratio and their concentrations, and applied voltage on chiral separation were investigated. Baseline resolutions of all the compounds were achieved with a mobile phase of 70:30 (v/v) ACN/MeOH containing 255 mM AcOH and 17.4 mM TEA under the applied voltage of –10 kV at 25 oC.

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