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  • 09월 05일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제120회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Multisubstituted Allenes, Furans, and Pyrroles via Tandem Palladium-Catalyzed Substitution and Cycloisomerization

2017년 8월 3일 16시 06분 47초
ORGN.P-247 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 20일 (금요일) 13:00~14:30
Organic Chemistry
저자 및
Da-Hye Jeon, Gi Hoon Ko, Phil Ho Lee*
Department of Chemistry, Kangwon National University, Korea

Recently, an efficient synthetic method towards multisubstituted furans and pyrroles bearing hetero-substituents was reported through metal-catalyzed 1,2-shifts of diverse migrating groups in allenyl systems. However, the introduction of a wide variety of substituents at the 4-position of furans and pyrroles is impossible due to requirement of [1,3]-H shift in these methods. Therefore, the development of an efficient synthetic method for multisubstituted furans and pyrroles bearing 3-heteroatom substituents as well as substituents at the 4-position has been a continuing challenge. Herein, we report Pd-catalyzed propargyl substitution reactions of propargyl acetates with indium organothiolates for the synthesis of multisubstituted allenyl sulfides. This procedure employed tandem Pd-catalyzed propargyl substitution and cycloisomerization reactions from indium organothiolates and propargyl acetates bearing acyl and imidoyl groups for the synthesis of multisubstituted furans and pyrroles in one-pot.This work was supported by the Human Resource Training Program for Regional Innovation and Creativity through the Ministry of Education and National Research Foundation of Korea (NRF-2015H1C1A1035955)