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  • 02월 19일 10시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제121회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of High Crystallinity Carbon Nano-spheres as Hyperpolarized MRI Probes for Cancer Diagnosis

2018년 2월 7일 16시 11분 48초
ANAL2.O-21 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 41분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
DOKYUNG KIM, Youngbok Lee1,*
Department of Bio-Nano technology, Hanyang University, Korea
1Department of Bio-Nano techology, Hanyang University, Korea
Carbon is widely used as a new material in a wide range of fields such as electric and electronic fields, mechanical and energy fields, and bio-medical and environmental fields. The properties of carbon such as a high affinity with biomaterials, paramagnetic properties, easily size control are great advantages that can be utilized as a hyperpolarized MR imaging probe. Biocompatibility and biodegradability of carbon make it possible to utilize particles even in vivo. In addition, flexible surface functionalization of carbon and surface pore make it possible to use the imaging probe as a theragnosis material to carry the drug to target cells. Carbon Nano Spheres(CNS), composed of polydopamine, are doped by nitrogen. So, stable free radicals present on the surface of CNS that can eventually be amplified by a DNP effect. To improve the DNP signal, CNS must have high crystallinity because high crystallinity has a long T1 time. Therefore, we had attempted to synthesize CNS with high crystallinity in various ways. 1) High temperature treatment : After high temperature treatment, 002 diffraction profile be shifted to high angle side and sharpened. With increasing temperature, carbon layers grew and the number of stacked layers increased. Therefore, turbostratic structure changes to graphite structure by high temperature. 2) Catalytic carbonization : Among the various transition metals, gold had a diamagnetic property that does not block the DNP signal was selected. So dopamine is coated on the gold which is synthesized into spheres and carbonized. At carbonization step, Gold particles work as catalysts for graphitization. Finally obtained CNS having high crystallinity can potentially be utilized as biocompatible and targetable imaging probe for hyperpolarized MRI researches.