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  • 02월 28일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제123회 대한화학회 학술발표회, 총회 및 기기전시회 SERS-based microdroplet system for high-throughput gradient analysis

2019년 2월 14일 16시 21분 46초
ANAL2.O-22 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 24분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
Jinhyeok Jeon, Kyoung Neon Kim1, Jaebum Choo1,*
Department of Bionano Technology, Hanyang University, Korea
1Departoemt of Chemistry, Chung-Ang University, Korea
Microfluidic technology has emerged as a highly efficient tool for the study of various chemical and biological reactions in last two decades. Recently, we reported that high-throughput biomarker detections can be achieved using a single phase gradient microfluidic channels together with surface-enhanced Raman scattering (SERS) detection. However, the deposition of nanoparticle aggregates on channel surfaces induces the “memory effect” in the continuous flow regime, thus affecting both sensitivity and reproducibility. To resolve this problem, a SERS-based gradient microdroplet system has been developed in this work. Herein, the sample stacking problem could be solved since two-phase liquid/liquid segmented flow reduces the memory effect. A serial dilution of a reagent could be also achieved in a stepwise manner using microfluidic concentration gradient generators. Therefore, desired concentrations of a reagent could be sequentially trapped by a small volume of droplets to prevent the sample stacking. We believe that this microdroplet system will be of significant utility in monitoring chemical and biological reactions for various concentrations of a reagent.