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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Intra-mitochondrial Disulfide Polymerization Controls Cancer Cell Necroptosis

등록일
2020년 5월 20일 16시 51분 23초
접수번호
2543
발표코드
ORGN.P-690 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
온라인 PDF 제출
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Ja-Hyoung Ryu*, Sangpil Kim1
Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
1Department of Molecular Science, Ulsan National Institute of Science and Technology, Korea
The energy consuming reactions to biological dissipative state are ubiquitous in biological system, and its mimicry is a great challenge in synthetic chemistry. Herein, we developed intra-mitochondrial polymerization strategy for constructing macroscopic structures by ROS-dissipative system. For the first time, we found that disulfide polymerization is occurred inside cancer mitochondria owing to high ROS concentration of cancer mitochondria, while the disulfide polymerization is hardly happened inside cell due to intracellularly reductive environment. Polymerization process of thiol-containing monomer increases ROS inside mitochondria, which enable the autocatalytic process to accelerate further polymerization and induce mitochondrial dysfunction. This in-situ polymerization shows great potential for anticancer treatment against various cancer cell lines including drug resistant cancer cell.

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