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  • 03월 08일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제127회 대한화학회 학술발표회 및 총회 Immunomagnetic Electrochemical Sensor for Extracellular Vesicle Analysis and Disease Diagnosis

등록일
2021년 2월 4일 11시 10분 52초
접수번호
0042
발표코드
ANAL1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 00분
발표형식
심포지엄
발표분야
Analytical Chemistry - Convergence Analytical Chemistry for Disease Diagnosis
저자 및
공동저자
Jongmin Park
department of Chemistry, Kangwon National University, Korea

Extracellular vesicles, including exosomes, are nanoscale membrane particles that carry molecular information on parental cells. They are being pursued as biomarkers of various diseases, especially cancer that are difficult to detect or serially follow. To solve this issue, we developed a compact sensor technology for rapid, on-site exosome screening. The sensor is based on an integrated magneto−electrochemical assay: exosomes are immunomagnetically captured from patient samples and profiled through electrochemical reaction. By combining magnetic enrichment and enzymatic amplification, the approach enables (i) highly sensitive, cell-specific exosome detection and (ii) sensor miniaturization and scale-up for high-throughput measurements. We demonstrated this system to screen extracellular vesicles in human body fluids such as plasma or urine samples from patients with ovarian cancer1, kidney transplant rejection2 and colorectal cancer patients3. The sensor allowed for the simultaneous profiling of multiple protein markers within an hour, outperforming conventional methods in assay sensitivity and speed.


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