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제127회 대한화학회 학술발표회 및 총회 Development of Nucleic Acid Nanoengineering-based Biosensor for Virus Detection

등록일
2021년 2월 16일 17시 18분 18초
접수번호
0309
발표코드
ANAL1-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 13시 : 20분
발표형식
심포지엄
발표분야
Analytical Chemistry - Convergence Analytical Chemistry for Disease Diagnosis
저자 및
공동저자
Taek Lee
Department of Chemical Engineering, Kwangwoon University, Korea
Since 2010, nucleic acid nanoengineering has been attracted for cancer treatment, gene delivery, bioimaging and therapeutic applications. Recently, the field of nucleic acid nanoengineering has been extended to biosensor and in vitro diagnostics because of high specificity to target bioprobe, thermodynamic stability of structure and easy-to-tailoring for embodying the functionality. Among them, virus is one of the harmful pathogens to human due to fast infection, mutants and high fatal rate. To detect the virus effectively, the author fabricated multi-functional nucleic acid-nanoparticle hybrid for virus biosensor application. As a multi-functional bioprobe, the DNA 3WJ was introduced. Each fragment of DNA 3WJ was rolled to recognition part (viral protein detection aptamer), signal transduction part and immobilization part, respectively. Each fragment was assembled to form the DNA 3WJ for virus detection and the assembled structure was confirmed by various techniques including the electrophoresis, atomic force microscopy and others. The nucleic acid nanoengineering will pave the way for various virus detection platforms. /Acknowledgements: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1D1A1B07049407) by Korea Environment Industry&Technology Institute(KEITI) through the program for the management of aquatic ecosystem health, funded by Korea Ministry of Environment(MOE).(2020003030001) by the Industrial Core Technology Development Program(20009121, Development of early diagnostic system of peritoneal fibrosis by multiplex detection of exosomal nucleic acids and protein markers) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea)

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