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제127회 대한화학회 학술발표회 및 총회 Electrochemical biosensors using a photoredox catalyst and a nanozyme

등록일
2021년 2월 16일 19시 37분 45초
접수번호
0342
발표코드
ELEC1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 35분
발표형식
심포지엄
발표분야
Electrochemistry - New Horizons for Molecular Electrochemistry and Its Applications
저자 및
공동저자
Haesik Yang
Department of Chemistry, Pusan National University, Korea
Two electrochemical biosensors using new catalytic reactions will be presented. In the first part, washing-free DNA detection using surface-plasmonic-field-induced photoredox catalysis will be introduced. A distance-dependent surface plasmonic field induces rapid photoredox catalysis of surface-bound catalytic labels, and distance-dependent mediated electron transfer allows for rapid electron transfer from the surface-bound labels to the electrode. An optimal system consists of a chemically reversible acceptor (Ru(NH3)63+), a chemically reversible photoredox catalyst (eosin Y), and a chemically irreversible donor (triethanolamine). In the second part, a sensitive immunosensor using a metal nanozyme with ester hydrolysis activity will be introduced. Metal nanoparticle surfaces are used for peroxidase- and oxidase-like nanozymes but not for esterase‐like nanozymes. It is found that metal nanoparticle surfaces rapidly catalyze non-redox ester hydrolysis in the presence of redox H3N−BH3 (AB). Metal hydrides are readily generated on a Pt nanoparticle (PtNP) from AB, and as a result the PtNP becomes electron-rich, which might assist nucleophilic attack of H2O on the carbonyl group of an ester. The nanozyme system based on PtNP, AB, and 4-aminonaphthalene-1-yl acetate provides an electrochemical signal-to-background ratio much higher than natural enzymes, due to the rapid ester hydrolysis and redox cycling involving the hydrolysis product.

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