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  • 03월 08일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제127회 대한화학회 학술발표회 및 총회 Advanced strategies for miRNA detection based on Graphene oxide

등록일
2021년 2월 18일 16시 53분 03초
접수번호
1043
발표코드
ANAL1-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 13시 : 00분
발표형식
심포지엄
발표분야
Analytical Chemistry - Convergence Analytical Chemistry for Disease Diagnosis
저자 및
공동저자
Jieon Lee
Predictive toxicology department, Korea institute of toxicology, Korea
MicroRNAs (miRNAs), short non-coding RNAs, have emerged as promising next-generation biomarkers of diverse diseases. In general, conventional quantitative real-time PCR and miRNA microarray methods have been utilized for the quantitative detection of miRNA. However, owing to their complicated procedures and expensive reagents/instruments, these methods cannot be widely applied by medical experts such as doctors and nurses, and are thus limited for practical clinical application. In this presentation, we introduce graphene oxide (GO)-based optical sensing strategies for miRNA with enhanced sensitivity, specificity, user-friendliness, scalability, and portability. They are fundamentally based on the physical/chemical/optical properties of GO and newly-designed functional DNA probes for miRNAs. They have potential for use in point-of-care testing (POCT), multiplex imaging, and reliable screening. We believe that these new GO-based sensors can be a suitable tool for miRNA-based practical diagnostics of diseases, and provides a valuable resource for basic and applied research.

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