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128th General Meeting of Korean Chemical Society Identification and Analysis of Biomarkers from Novichok-inhibited Human Plasma

Submission Date :
8 / 24 / 2021 , 10 : 08 : 10
Abstract Number :
128082446307
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Woo-Hyeon Jeong
Chem-Bio Technology Center, Agency for Defense Development, Korea
Assigned Code :
ANAL2.O-14 Assigend Code Guideline
Presenting Time :
FRI, 10 : 18
NOVICHOK is a series of novel nerve agents reported firstly in Skripal Attack in 2018. We identified biomarkers from Novichok-inhibited human plasma for verification purposes. Butyrylcholinesterase and Human Serum Albumin were chosen for the target of biomarker identification using protease digestion and estimated the structure and exact mass of Novichok-inhibited biomarkers based on finding for conventional nerve agents. We successfully detected biomarkers for verification against Novichok in human plasma, and their MS2 Spectra was assigned and utilized for further analysis of OPCW Biomedical Proficiency Test (BioPT) or authentic plasma samples.