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128th General Meeting of Korean Chemical Society Dynamic Nuclear Polarization of Selectively 29Si Isotope-Enriched Silica Nanoparticles

Submission Date :
8 / 26 / 2021 , 12 : 11 : 26
Abstract Number :
128082646317
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Jiwon Kim, Donghyeok Jo1, InCheol Heo2, Won Cheol Yoo3,*, Youngbok Lee4,*
Department of Bionano technology, Hanyang University, Korea
1Department of Bionano Technology, Center for Bionano intelligence Education and Research, Hanyang University, Korea
2Department of Applied chemistry, Hanyang University, Korea
3Department of Chemical and Molecular Engineering, Hanyang University (ERICA), Korea
4Department of Bio-Nano Engineering, Department of, Korea
Assigned Code :
ANAL2.O-11 Assigend Code Guideline
Presenting Time :
FRI, 10 : 00
Silica nanoparticles have garnered attention as promising biomedical probes for hyperpolarized 29Si magnetic resonance imaging and spectroscopy. We have demonstrated a straightforward method of synthesizing selectively 29Si enriched nano-sized silica particles with high degrees of control in terms of the particles’ physicochemical properties and size. By utilizing 100% 29Si enriched TEOS, a silica precursor, selective enrichments on either particle surface (10 nm thickness) or core (40 nm diameter) were precisely conducted. With the particles of various structural characteristic, dynamic nuclear polarization (DNP) properties ranging from buildup, enhancement factor, and depolarization time at a cryogenic temperature were examined. The best considerable signal amplification was achieved from the silica nanoparticle with a selective enrichment localized on the particle surface, exposing both the successive surface polarization and polarization profile. The synthetic strategy with selective enrichments on the particles may expand the practical applicability of the nano-sized silica materials in various biomolecular processes, including targeted molecular imaging in vivo.