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128th General Meeting of Korean Chemical Society Engineering and Identification of Marine Bioactive Peptide to Enhance the Properties of Antioxidant and Anti-inflammatory

Submission Date :
8 / 31 / 2021 , 13 : 11 : 59
Abstract Number :
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Soyun Choi, Dong-Ku Kang*
Department of Chemistry, Incheon National University, Korea
Assigned Code :
ANAL2.O-13 Assigend Code Guideline
Presenting Time :
FRI, 10 : 12
It has been discovered that various marine active peptides have antioxidant and anti-inflammatory activities. QHGV (glutamine-histidine-glycine-valine), oyster-derived peptide has been widely investigated its’ anti-aging and anti-inflammatory functions. Here, QHGV peptide is modified by adding various naturally-derived phenolic acids, which has C-3 methoxy radicals or C-4 hydroxyl in aldehyde or benzyl alcohol. Five types of phenolic acids are selected to provide superior antioxidant effects and phenolic acids were conjugated at the end of N-terminus. Cellular ROS was more decreased by Phenolic acid-conjugated QHGV comparing non-modified QHGV and phenolic acid conjugated does not induce cellular toxicity in HaCaT cells. In addition, Phenolic acid induces collagen expression of mRNA and protein level in HaCaT cells. It has been also well-identified that oxidative-stress relates with inflammatory responses. Therefore, effect of phenolic acid conjugation was characterized on anti-inflammatory property of QHGV peptide. Results indicate that phenolic acid conjugation inhibits LPS-induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mRNA level. These results suggest that modification of phenolic acid provides additional and stronger biological activities on QHGV peptides.