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128th General Meeting of Korean Chemical Society Maximization of chiral chromatography efficiency through temperature control

Submission Date :
8 / 31 / 2021 , 12 : 17 : 15
Abstract Number :
128083146377
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Danbi Eun, Jae Jeong Ryoo1,*
Dept. of Chemistry Education, Kyungpook National University, Korea
1Department of Chemical Education, Kyungpook National University, Korea
Assigned Code :
ANAL2.O-10 Assigend Code Guideline
Presenting Time :
FRI, 09 : 54
The separation of two enantiomers is very important in many scientific fields.[1] If the enantiomers are separated and the two separated peaks are far apart, it is because the interaction between the two enantiomers of sample and the chiral selector (stationary phase material in the chiral column) is good and shows a large separation factor value. In addition, when the base line of the two peaks of the separated enantiomers is clearly separated, it shows a large resolution value, is effective for mass separation of chiral compounds, and it is advantageous to obtain optically pure chiral compounds from a practical point of view. In this study, how effectively the separation was changed in terms of separation factor (a) and resolution (Rs) through manual temperature control in the separation of two enantiomers of a racemic mixture for five chiral compounds[2,3] (N-3,5-DNB-DL-Leucine, N-3,5-DNB-DL-Alanine, N-3,5-DNB-DL-Phenylalanine, N-3,5-DNB-DL-Valine, N-3,5-DNB-DL-Phenylglycine) using HPLC. Through this study, it was confirmed that the analysis efficiency can be significantly increased through simple heating/cooling in HPLC. [1] Ward TJ, Ward KD. Chiral separations: a review of current topics and trends. Anal Chem 2012;84:626–635. [2] Yu JJ, Ryoo DH, Lee JM, Ryoo JJ. Synthesis and Application of C2 and C3 Symmetric (R)-Phenylglycinol-Derived Chiral Stationary Phases. Chirality 2016;28:186-191. [3] Ryoo JJ, Kim TH, Im SH, Jeong YH, Park JY, Choi SH, Lee KP, Park JH. Enantioseparation of racemic N-acylarylalkylamines on various amino alcohol derived π-acidic chiral stationary phases. J Chromatogr A 2003;987:429-438.