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128th General Meeting of Korean Chemical Society Biomedical applications of stimuli responsive nanoparticles

Submission Date :
9 / 8 / 2021 , 10 : 29 : 46
Abstract Number :
128090847046
Presenting Type:
Symposium
Presenting Area :
Polymer Chemistry - Special Symposium by Mid-career Biomaterials Scientists
Authors :
In-Kyu Park
Department of Biomedical Sciences, Chonnam National University, Korea
Assigned Code :
POLY1-3 Assigend Code Guideline
Presenting Time :
THU, 16 : 40
Hydrogen peroxide are most potent reactive oxygen species (ROS) linked with major diseases such as cancer, and inflammatory diseases. In case of cancer, H2O2 produced during hypoxic condition in the tumor supports the cancerous cells to proliferate and metastasize to other organs. Hence, the H2O2 could be the possible therapeutic target for subsidizing the inflammatory and cancerous condition. Here, we developed a manganese dioxide based albumin nanoparticle self-assembled with cationic polymers and forming stable nanoassembly for mitigating LPS induced inflammation in mice model. Our results demonstrated that nanoassembly exhibited low cytotoxicity and remarkable scavenging of H2O2 in LPS induced macrophage cells as well as in locally inflamed paw site of mice. In systemic inflammation, nanoassembly reduced the secretion of proinflammatory cytokines like TNF-α and IL-6 and therefore led to prevention of inflammatory microglial mediated neuroinflammation.
In cancer photo-immunotherapy application, hydrogel loaded manganese dioxide based albumin nanoparticle were used along with adjuvants. Here, photothermal mediated tumor reduction in 4T1 breast cancer tumor upon near-infrared (NIR) laser irradiation were significant compared to control treatment. The manganese dioxide reduced hypoxia in the tumor, that leads to prevention of epithelial to mesenchymal transition (EMT).
Overall, manganese dioxide based albumin nanoparticles showed great potential for photothermal mediated anti-cancer therapy as well as in mitigating LPS induced inflammation. Therefore, this nanoparticle could be beneficial for future clinical applications.