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  • 09월 05일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제128회 대한화학회 학술발표회, 총회 및 기기전시회 Biomedical application of Polypeptide & Nanosystem for cancer therapy

2021년 9월 16일 17시 11분 37초
POLY1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 17시 : 10분
Polymer Chemistry - Special Symposium by Mid-career Biomaterials Scientists
저자 및
Yeu Chun Kim
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Korea
Cell-penetrating peptides (CPPs) have been widely used to deliver nucleic acid molecules. Generally, CPPs consisting of short amino acid sequences have a linear structure, resulting in a weak complexation and low transfection efficacy. To overcome these drawbacks, a novel type of CPP is required to enhance the delivery efficacy while maintaining its safe use at the same time.
Herein, artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. And we report an artificial apoptosis-inducing polypeptide that destabilizes the mitochondrial membrane and transports calcium ions into the cytosol, thereby synergistically creating severe oxidative conditions. The oxidative stress highly activates an apoptotic signaling cascade, and also inhibits cell migration and invasion in vitro and in vivo. The suggested strategy for simultaneous mitochondrial disruption and perturbed calcium homeostasis demonstrates the applicability of polypeptide-based therapeutics as potent apoptosis-inducers in cancer therapy.