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  • 09월 05일 23시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제128회 대한화학회 학술발표회, 총회 및 기기전시회 Biomarker Discovery and Diagnostics for Human Health

2021년 9월 23일 10시 56분 30초
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목 17시 : 20분
Analytical Chemistry - Recent Studies in Bioanalyses Using Non-human Subjects
저자 및
Wonryeon Cho
Department of Chemistry, Wonkwang University, Korea
Cancer, one of the refractory diseases, is still a challenging problem for all of mankind. Targeted glycoproteomics using affinity chromatography (AC) was used to identify and quantify cancer-related glycoproteins with cancer and normal plasma from breast cancer and colon cancer patients in U.S.A. Then after returning to Korea, AC was used to isolate and identify potential cancer biomarker glycoproteins by targeting disease-associated glycans between cancer patients and healthy control groups. For this research, several types of cancer patients’ plasma were collected from several hospitals and lung cancer was at first studied on the basis of traditional Korean medicine. Then colon cancer biomarkers were found using self-packed Con A and SNA serial affinity chromatography in human plasma. Exosome proteins in plasma were also discovered in lung cancer patients. Recently, prostate cancer tissues have been used for better biomarkers using PSA As a control group for cancer patients, healthy elderly people were evaluated and categorized based on aging and exercise levels in elderly yoga programs through lectin based glycoproteomics, which was consistent with the triglyceride and glucose (TyG) Index used in the doctor’s office. The potential of these candidates as cancer biomarkers remains to be validated in much larger and more diverse populations of cancer patients. Sample Displacement Chromatography (SDC) was also developed for glycan heterogeneity differentiation in cancer biomarker discovery. Efficacy of natural antibacterial feeds were also evaluated for aquaculture using proteomics.
The ultimate goal is to develop simple and economical cancer diagnostics kits by immobilizing cancer-related proteins in plasma on the biocompatible coatings for human health. The disease diagnostic kits have several selected antibodies which can be immobilized on the inorganic surfaces with their native structures for their activities. As a result, biocompatible polymer coatings were used to build up nanostructures on these surfaces and then applied to BioCD products and chromatography columns for commercial use.