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129th General Meeting of Korean Chemical Society & Exposition The efficacy of prostate cancer diagnosis using PSA between blood test and cancer tissues

Submission Date :
2 / 17 / 2022 , 15 : 17 : 33
Abstract Number :
129021730317
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Miseon Jeong, Wonryeon Cho*
Department of Chemistry, Wonkwang University, Korea
Assigned Code :
ANAL2.O-11 Assigend Code Guideline
Presenting Time :
FRI, 09 : 40
As a protein biomarker, prostate-specific antigen (PSA) in blood has been widely used for the early diagnosis of prostate cancer (PCa) in clinics. However, PSA also increases in other prostate diseases, such as benign prostatic hyperplasia (BPH) and prostatitis. This leads to a higher number of false positives and causes unnecessary biopsies, an invasive procedure which is associated with risks including bleeding and sepsis. This study intended to identify PSA information from different prostate cancer tissues with different PSA values in patients’ blood to discover relationship between blood and cancer tissues for a more accurate early diagnosis. PCa tissues were collected from the PCa patients, homogenized, and proteins were extracted from the homogenized PCa tissues. Then each supernatant fluid was trypsin digested and desalted respectively, and the proteins in all PCa tissues were identified and quantified using nLC-MS/MS and protein database search softwares.