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129th General Meeting of Korean Chemical Society & Exposition Quantitative Analysis of Anti-cancer Drugs and Its Fragmentation Pathways Using Ion Mobility Mass Spectrometry and Tandem Mass Spectrometry

Submission Date :
2 / 18 / 2022 , 18 : 45 : 15
Abstract Number :
129021830377
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Gyusub Yoon, Sooyeon Chae, MyungKook Son, Dongjoon Im, Dongvin Kwak, Da Gyeong Hyun, Chanju Won, Hugh I. Kim*
Department of Chemistry, Korea University, Korea
Assigned Code :
ANAL2.O-17 Assigend Code Guideline
Presenting Time :
FRI, 10 : 04
Neuroblastoma is one of the representative childhood cancers and a highly heterogeneous disease affected by factors such as age at diagnosis, stage, and tumor biology. Multidrug regimen chemotherapy has been ongoing for high-risk patients and requires customizing to maximize treatment efficiency. To improve the outcomes for neuroblastoma, many research groups and institutes have developed precision medicine (personalized-medicine) using biochemical methods such as genomics and proteomics. Among them, pharmacogenomics and pharmacoproteomics are broader academic fields that identify genes or proteins involved in drug response or disease occurrence. Therefore, It is important to verify pharmacokinetics to develop pharmacogenomics and pharmacoproteomics. In this study, we establish a drug quantitation method for verifying pharmacokinetics using mass spectrometry. Quantitative analysis of Intracellular antidrug was performed using multiple reaction monitoring (MRM) analysis using RPLC-triple quadrupole mass spectrometry. For precise quantitative analysis, the mechanism of fragmentation used in MRM analysis was also investigated. Fragmentation pathways of anticancer drugs were identified using ion mobility mass spectrometry (IM-MS).