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129th General Meeting of Korean Chemical Society & Exposition Engineering Oxidase-Mimicking Activity of Dendrimer-Encapsulated Pt Nanoparticles

Submission Date :
2 / 28 / 2022 , 16 : 46 : 37
Abstract Number :
129022830467
Presenting Type:
Oral Presentation
Presenting Area :
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
Authors :
Hyein Lee, Joohoon Kim*
Department of Chemistry, Kyung Hee University, Korea
Assigned Code :
ANAL2.O-26 Assigend Code Guideline
Presenting Time :
FRI, 10 : 40
Here, we report the engineered oxidase-mimetic activity of dendrimer-encapsulated Pt nanoparticles (Pt DENs) by precisely controlling their sizes in the diameter range of 1.8 – 3.1 nm. Using a dendrimer-template method, we synthesized five different Pt DENs (i.e., Pt200, Pt220, Pt550, Pt880, and Pt1320 DENs) having sizes in the range of 1.8 – 3.1 nm. The as-synthesized Pt DENs exhibit oxidase-mimetic activity for the oxidation of Amplex Red to form fluorescent resorufin in the presence of oxygen. Mechanistic study indicates that Pt DENs catalyzed activation of dissolved oxygen to generate reactive oxygen species (ROSs) (i.e., OH•, O2•-, and 1O2) and the ROSs are responsible for the oxidation of Amplex Red to resorufin. The enzyme-mimetic activity of Pt DEN was tunable by changing the size of Pt nanoparticles, and especially up to Pt1320 DENs with a diameter of 3.1 nm. The oxidase-like activity of Pt DENs tends to increase as their size increased. Interestingly, Pt1320 DENs exhibit a ~117-fold higher catalytic activity compared to Pt200 DENs, although they were only 1.2 nm larger in diameter than Pt200 DENs. We envision that this study can provide insights into the design of artificial enzymes having excellent performance.