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129th General Meeting of Korean Chemical Society & Exposition Chiral Nanomaterials for Next Generation Bio-Science and Technology

Submission Date :
3 / 10 / 2022 , 09 : 40 : 00
Abstract Number :
129031030516
Presenting Type:
Symposium
Presenting Area :
Analytical Chemistry - Recent Development of Diagnostic Virus Sensing for Post-Covid19
Authors :
Jihyeon Yeom
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, Korea
Assigned Code :
ANAL1-3 Assigend Code Guideline
Presenting Time :
THU, 16 : 20
Chirality is ubiquitous in nature and is hard-wired into every living biological system. The well-known examples are L-type amino acids and D-type nucleic acids and glycans. Since the chirality of building blocks decides the handedness of assembled structures, proteins such as enzymes and receptors are also chiral. Importantly, their chiral structures are closely related to their biological properties. For example, depending on the chirality of molecules that are consumed or reach the taste buds or olfactory receptors, they taste sweet or bitter, and smell differently. These chiral-sensitive receptors are not just limited to the tongue or nose, but distributed in the stomach, intestine, and pancreas that govern overall physiology. Likewise, chirality is an important architectural consideration to build an effective artificial enzyme.

There have been enormous efforts to mimic enzymatic functionalities by developing artificial structures to utilize them under relatively harsher conditions than that in the body. However, due to the limited stability and the lack of high selectivity, it has still remained challenging. Using inorganic materials is a powerful strategy to solve these problems. Due to the thick electron clouds, inorganic materials show high catalytic activity, sensitivity, and stronger interactions with electric, electromagnetic and magnetic fields that amplify the signal. Thus, nanostructures designed with inorganic materials and biomimetic properties will offer efficient signal transition/ amplification, higher chemical and physical tolerance, and multi-functionality.

In the talk, I will convey how chiral engineering using inorganic nanostructures will provide “smart” platforms, a new level of control for drug delivery systems, tumor detection markers, biosensors, and other biomaterial based devices.