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130th General Meeting of Korean Chemical Society Solubilization formation of rebamipide solid dispersion with various polymers

Submission Date :
8 / 4 / 2022 , 11 : 06 : 12
Abstract Number :
Presenting Type:
Poster Presentation
Presenting Area :
Industrial Chemistry
Authors :
Youngjun Son, Seung Jae Kim, Seung Ho Choe, Taewoong Kang, Jeong Eun Song, Gilson Khang1,*
Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, Korea
1PolymerNano Science & Technology and Polymer Materials Fusion Research Center, Jeonbuk National University, Korea
Assigned Code :
Presenting Time :
To increase the solubility of the poorly soluble drug Rebamipide (RBM), a solid dispersion (SD) was prepared by using a spray drying method. The solid dispersion was prepared by hydroxypropylmethylcellulose(HPMC), which is a water-soluble polymer for solubility, and an ionic surfactant was additionally added to adjust the pH through NaOH. In addition, the solubility of SD according to surfactants was measured. The characteristic analysis of the produced SD was compared and analyzed using Scanning Electron Microscopy (SEM), and the crystallinity of SD was analyzed using differential scanning calorimetry and X-ray diffraction. Furthermore, we analyze the characteristic changes in the chemical structure of SD using Fourier-transform infrared spectroscopy. As a result, it was confirmed that RBM was transformed from crystalline to amorphous in SD form. When the solubility of SD was analyzed using High-Performance Liquid Chromatography (HPLC), the dissolution rate of SD with the addition of the surfactant Kolipor P407 and span was relatively higher than that of pure drugs and other samples. In vitro release behavior was investigated in simulated gastric fluid, and it was confirmed that solubilization of the drug was formed by comparing the dissolution rate with the comparator Mucosta Tab(Otsuka Pharmaceutical Korea) in HPMC-based SD. This work was supported by the material, parts technology development project (package type) (20013651, Development of an aseptic sterilizer for producing biopharmaceuticals by control pressure 0.01Mpa 1.0 precision based on AL Fuzzy) funded by the Ministry of Trade, industry & Energy (MOTIE, Korea).