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130th General Meeting of Korean Chemical Society Activity-Based Sensing Approaches to Decipher Transition Metal and Single-Atom Signaling

Submission Date :
8 / 4 / 2022 , 16 : 32 : 39
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KCS - [KCS Editors’ Symposium] Leading Scientists in Understanding and Regulating Chemical Structures and Reactions
Authors :
Christopher J. Chang
Department of Chemistry and Molecular and Cell Biology, University of California, United States
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Traditional strategies for developing selective imaging reagents rely on molecular recognition and static lock-and-key binding to achieve high specificity. We are advancing an alternative approach to chemical probe design, termed activity-based sensing, in which we exploit inherent differences in chemical reactivity as a foundation for distinguishing between chemical analytes that are similar in shape and size within complex biological systems. This presentation will focus on development of activity-based sensing probes to visualize dynamic fluxes of metal ions and reactive oxygen species and their signal/stress contributions to living systems, along with activity-based proteomics to identify novel targets and pathways that these emerging classes of chemical signals regulate.