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130th General Meeting of Korean Chemical Society DNA Barcode Sorting of Valency Defined Nano-Synthons

Submission Date :
8 / 4 / 2022 , 17 : 01 : 33
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KCS - [KCS Editors’ Symposium] Leading Scientists in Understanding and Regulating Chemical Structures and Reactions
Authors :
Haw Yang
Department of Chemistry, Princeton University, United States
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Thinking of nanoparticles tagged with a defined number of DNA molecules as ‘nano-synthons’ continues to inspire new pathways for developing novel materials and nanotechnologies. Yet, practical limitations have prevented the community from effectively translating this powerful idea to real-world applications: available nano-synthons are confined to small nanoparticles (typically sizes <40 nm), and they can only be produced in analytical amounts (sufficient only for single-particle proof-of-principle demonstrations). Here we describe a new concept capitalizing on the digital nature of DNA hybridization to enable reagent-scale purification of valency-defined nanoparticles of various sizes, shapes, and materials. We discuss the underlying physical principles and how they can be understood quantitatively. We show one-step synthesis of various artificial molecule bonding modes that could be of potential interest. If time allows, we will also discuss new theories and experiments for plasmon-enhanced spectroscopies inspired by this concept.