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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Solid-Phase Synthesis of 1,2,4-thiadiazole Derivatives via Cyclization of thiourea Carboxamidine Resins

등록일
2008년 2월 12일 11시 09분 24초
접수번호
0869
발표코드
33P226포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
류인애, 이태임1, 이태호1, 하덕찬, 공영대1
고려대학교 화학과,
1한국화학연구원 신약기반기술연구센터,
Solid-Phase synthesis of combinatorial libraries has emerged as a powerful tool for efficient drug discovery process. As a part of our high-throughput synthesis program for drug discovery, we are trying to explore the potential of resin-bound carboxamidine thioureas as versatile intermediates for generation of drug-like five-membered heterocyclic compound libraries. Herein we would like to present novel solid-phase synthetic method for combinatorial generation of 5-amino substituted-1,2,4-thiadiazole based library through isothiocyanate resin. 1,2,4-thiadiazoles have been used as privileged scaffolds to produce substances of interest in numerous therapeutic areas, such as antiimflammatory, antimicrobial, anticonvulsant. The progress of reactions could be monitored as solid-bound intermediates by ATR-FTIR spectroscopy. The final compounds were obtained in good yields and high purities upon cleavage from the resins.

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