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  • 02월 22일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Nanoparticles-based nanomedicine for cancer treatment

등록일
2008년 2월 12일 16시 08분 50초
접수번호
1013
발표코드
금22K4심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 40분
발표형식
심포지엄
발표분야
재료화학 - Materials Chemistry of Nano and BioSciencesⅡ
저자 및
공동저자
전상용
광주과학기술원 생명과학과,
We report 1) the fabrication of an antibiofouling polymer-coated TCL-SPION that bear near IR dyes and doxorubicin (Dox, an anticancer drug) and 2) their application to cancer imaging and therapy in vivo. When TCL-SPION was administered to tumor allografted mice by intravenous injection, the tumor was unambiguously detected in T2-weighted magnetic resonance images as well as in optical fluorescence images within 4 h, indicating a high level of accumulation of the nanomagnets within the tumor site. At least 2 times higher accumulation of the anticancer drug, doxorubicin was observed at the tumor area with Dox-loaded TCL-SPION compared to the case of free Dox. In addition, the DOX@TCL-SPION showed exceptional anti-tumor effects without any systemic toxicity.

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