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Discovery of Novel Inhibitors to SARS-CoV Main Proteases

등록일
2008년 2월 13일 14시 34분 11초
접수번호
1119
발표코드
33P244포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
안태영, 하덕찬, Po-Huang Liang1, 정영식2
고려대학교 화학과,
1Institute of Biological Chemistry, Academia Sinica, Taiwan,
2한국화학연구원 신약연구단,
Picornaviruses (PV) are small non-enveloped RNA viruses that cause common cold and foot-and-mouth diseases. Coronaviruses (CoV) are large positive-stranded RNA viruses that typically cause respiratory and enteric diseases in humans and domestic animals. However, a novel human CoV causes severe acute respiratory syndrome (SARS) with high mortality rate. No effective drug is available for these diseases yet. PV has a chymotrypsin-like cysteine protease (3C protease) essential for viral replication, which is a promising drug target. However, its peptidomemetic irreversible inhibitor AG7088 could not inhibit the 3C-like protease of SARS-CoV, indicating some differences in the active-site structures. Through the high throughput screening we identified several novel inhibitors of SARS 3CL protease with IC50 of low μM. These inhibitors could be potentially developed into anti-viral agents.

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