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Synthesis Of New Bispyridinium Oxime Reactivators For Acetylcolinesterases Inhibited By Organophosphorus Agents

등록일
2008년 2월 13일 14시 40분 52초
접수번호
1121
발표코드
33P245포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
정희춘, 박노중1, 염을균, 박노상2, 정영식3
충남대학교 화학과,
1한국화학연구원 Bio-Refinery,
2한국화학연구원 화학물질연구부 중추신경연구실,
3한국화학연구원 신약연구단,
Exposure to the organophosphorus agents such as sarin, soman, parathion and marathion causes acute intoxication. It is well known that these organophosphorus agnets exert their biological effects by inhibiting acetylcholinesterase(AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. The inhibition of AChE increases the amount of acetylcholine at central and peripheral sites of the nervous system. The organophoshorus agents inhibited AChE can be reactivated by introducing nucleophiles such as pyridinium oximes. This oxime-induced reactivation is the primary therapeutic approach to organophosphorus poisoning. The search for more effective bispyridinium oxime reactivators is a focus of research program aimed at treating poisoning due to organophosphorus insecticides and chemical warfare agents.

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