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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Detection of EGFR Mutation by Partially dHPLC Method

등록일
2008년 2월 14일 11시 43분 47초
접수번호
1326
발표코드
31P63포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
조민호, 남윤형, 박수민, 안영창, 서재원, 윤일규, 정덕현, 장원철1
단국대학교 화학과,
1단국대학교 첨단과학대학,
Mutations in the epidermal growth factor receptor (EGFR) have recently been described in patients with advanced non–small-cell lung cancer (NSCLC). These mutations are detected in 10% to 15% of all patients with NSCLC and in 80% of patients who clinically respond to EGFR tyrosine kinase inhibitors gefitinib or erlotinib. These mutations are located in exons 18 to 21 of the EGFR tyrosine kinase domain and, to date, ~35 different variants have been described in NSCLC, head and neck, colon, and breast carcinomas. This study, we screened 106 lung cancer specimens for mutations in exons 18 to 21 of EGFR by partially dHPLC. As a results, the overall distribution of alleles was different between exons of EGFR gene. There were evidences for genetic association conferred by the EGFR gene with lung cancer.

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