abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Probing the Diverse DNA Sstuctures using the Fluorescent Nucleoside System

등록일
2008년 2월 14일 11시 50분 41초
접수번호
1337
발표코드
31P66포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
이일준, 김병현
포항공과대학교 화학과,
Monitoring the structural state of the biomolecules in solution phase is important for understanding them. Because noncovalent interactions between aromatic molecules (generally fluorophore) are often important for stabilizing organized structures formed from biological molecules, we have synthesized and applied various fluorescent nucleoside derivatives for probing secondary structures of nucleic acid. In oligonucleotides, not only the stacking between the fluorophores but the interaction between the fluorophore and DNA base induce the stable form and make possible of the monitoring the conformational diversity of DNA. As recognizing the interaction between DNA base and fluorophore, we could design and synthesize various fluorescent oligonucleotide systems for monitoring various DNA secondary structures, such as quencher-free molecular beacon, B-Z transition, G-quadruplex structures and i-motif and discover unique properties of fluorescent nucleosides.

상단으로