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  • 02월 22일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Total synthesis of (±)-aspidospermidine via the regioselective Stille coupling and Diels-Alder reaction of 3,5-dibromo-2-pyrone

등록일
2008년 2월 14일 14시 42분 24초
접수번호
1394
발표코드
32P245포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅴ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이한규, 조천규
한양대학교 화학과,

The Aspidosperma family represents one of the largest groups of indole alkaloids, with more than 250 compounds isolated from various natural sources. Because of their intriguing biological activities as well as the unique pentacyclic structural features, intense study has been directed toward their total synthesis over the past 40 years. In order to explore the potential applicability of 2-pyrone Diels-Alder strategy to the target-oriented synthesis, we have investigated the total synthesis of aspidospermidine with the maximum use of the resultant densely functionalized cycloadduct. More importantly, our study would establish a platform for the synthesis of various other structurally related aspidosperma alkaloids including tabersonine, catharanthine, vindoline as well as aspidophytine.


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