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  • 02월 22일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Self-Assembly of Well-Defined Copolypeptides

등록일
2008년 2월 14일 16시 18분 53초
접수번호
1414
발표코드
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발표시간
목 15시 : 40분
발표형식
심포지엄
발표분야
고분자화학 - Functional Soft Materials: Synthesis and ApplicationsⅠ
저자 및
공동저자
Hermis Iatrou, Nikos Hadjichristidis
Chemistry Department, University of Athens, Greece,
A series of novel amphiphilic triblock copolypeptides, poly(L-lysine)-b-poly(γ-benzyl-L-glutamate)-b-poly(L-lysine), was synthesized by: a) the sequential ring opening polymerization of γ-benzyl-L-glutamate and ε-Boc-L-lysine N-carboxy anhydrides, with 1,6-diaminohexane as initiator, using high vacuum techniques and b) the subsequent selective deprotection of the Boc- groups. Due to the macromolecular architecture of the tribock copolypeptides and the rigid nature of the poly(γ-benzyl-L-glutamate) middle block, the formation of bilayers was favored, and vesicles formed in water at neutral pH over the entire compositional range. Compared to other vesicular structures derived from conventional polymers, these polypeptidic vesicles possess the unique feature of being stimuli-responsive to pH and temperature. In the presence of deoxyguanosine monophosphate, a multilevel self-assembly of the triblock copolypeptides in water was observed.

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