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  • 02월 22일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Enantioselective Pauson-Khand Type Reaction by Rh(I) and Its Applications

등록일
2008년 2월 18일 16시 07분 17초
접수번호
1451
발표코드
목18F1심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 30분
발표형식
심포지엄
발표분야
유기화학 - Diversity in Organic Chemistry : Organic Synthesis and Synthetic Method
저자 및
공동저자
정낙철
고려대학교 화학과,
We have introduced the first rhodium catalyzed enantioselective PKR under CO atmosphere many years ago (Scheme). The early results in terms of enantioselectivity were promising, but had shown some limitations with a certain class of substrates as well. In an effort to optimize the reaction, we have examined the effects of various parameters, which are supposed to influence the chemical yield and stereoselectivity in this protocol. These studies include the effects of CO concentration, the electronic and steric factors of ligands, the electron density of the alkyne of substrates, and the reaction temperature. Both the character of the ligands and the substrates played important role. In addition, we noticed that many possible pathways are in competition. Based on the data we obtained, we wish to propose a unified mechanistic picture. In addition, the development of enantioselective reaction at ambient temperature, the desymmetrization of prochiral substrates, and the kinetic resolution from the racemic substrates were realized as well.

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