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제107회 대한화학회 학술발표회, 총회 및 기기전시회 Plasmonic Nanomaterials for smSERS(single molecule Surface-Enhanced Raman Scattering)

2011년 2월 26일 07시 05분 22초
MAT2-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 15시 : 15분
재료화학 - Emerging Photonic Nanomaterials
저자 및
한국화학연구원 나노바이오융합 연구센터, Korea
Since smSERS was independently reported by S. Nie group and K. Kneipp group in 1997, tremendous amount of interest has been shown to this field because Raman spectroscopy can provide molecular fingerprint together with multiplexing capability in bioassay. Regarding to the origin of this smSERS phenomena, so called “SERS hot spot”, these two groups argued against each other for several years: Nie group argued sharp edge in nanostructure, such as corners of a silver nanorod or even of a single nanoparticle, can play as a hot spot of smSERS, while Kneipp group argued they could observe smSERS signal only from colloidal aggregation in solution. Later on, Brus group and others showed that SERS hot spots, formed at the junction of two nanoparticles, likely play a major role in smSERS. However, formation of these smSERS-active nanostructures, mostly dimer or colloidal aggregation of Ag or Au nanoparticles adsorbed with Raman active molecules (e.g., Rhodamine 6G), is a random process driven by salt-induced non-specific aggregation. This fact has been a main hurdle for smSERS toward advanced applications. Based on the idea that controlling this nano gap between two noble metal nanoparticles is the key to realize reliable smSERS, we have designed a gold-silver nano dumbbell (GSND). Two gold nano particles with different sizes were linked to each other by double helix DNA (30mer), with a single Raman dye molecule labeled at the center position, to fix the two at a known gap distance (~10 nm). Then we narrowed the gap down to < 1 nm by standard silver staining method to endow the GSND with single molecule sensitivity. We have successfully detected smSERS signals, as well as typical single molecular blinking and polarization behaviors, from each GSNDs by Nano Raman spectroscopy at the single particle level.