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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Encoded Microparticles and Partipetting for High Throughput Material Chemistry

2011년 8월 1일 22시 56분 24초
MAT1-8 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 17시 : 10분
재료화학 - Microfluidic-Based Materials Chemistry
저자 및
권성훈, 정수은1, 이승훈1, 송영훈1, 김지윤1
서울대학교 전기공학부, Korea
1서울대학교 전기컴퓨터공학부, Korea

In drug discovery, the process of identifying drug target requires screening hundreds of thousands of drug libraries, which is like searching for a needle in a haystack. To deliver each chemical or biological compound to the assay system, a quantitative liquid handling technique is essential in high-throughput manner. Encoded particles have a demonstrated value for multiplexed high-throughput bioassays such as drug discovery and clinical diagnostics. In diverse samples, the ability to use a large number of distinct identification codes on assay particles is important to increase throughput. Proper handling schemes are also needed to readout these codes on free-floating probe microparticles. Herein, the pivotal point in drug screening process is how to handle million different chemicals in a simple and fast way. In this talk, we present a bioassay platform for high-throughput drug screening based on encoded drug-laden microparticles via a single step, using a method named as ‘partipetting’. Partipetting is defined as a method of delivering encoded drug-laden microparticles to chemically isolated reaction wells via fluidic self-assembly. The partipetting enables parallel handling of millions of different drugs making heterogeneous bioassay platform at once, thus greatly reduces the repetition of drug introduction into the microwell platform.