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108th General Meeting of Korean Chemical Society Unprecedented 3D Molecular Architectures by the Controlled Self-Assembly of Foldamers

Submission Date :
8 / 26 / 2011 , 13 : 25 : 46
Abstract Number :
Presenting Type:
Award Lecture in Division
Presenting Area :
유기화학 - Recent Trends in Organic Chemistry
Authors :
KAIST 화학과, Korea
Assigned Code :
ORGN-1 Assigend Code Guideline
Presenting Time :
목 13시 : 30분
Molecular self-assembly is the spontaneous assembly of molecules into structured aggregates by which nature builds complex functional systems. While numerous examples have focused on 2D self-assembly to understand the underlying mechanism and mimic this process to create artificial nano- and microstructures, a limited progress has been made toward 3D self-assembly on the molecular level. This lack of progress is partially due to the difficultly of designing and using nondirectional noncovalent interactions, such as van der Waals and hydrophobic interactions, in synthetic, nonbiological molecular systems. Thus, we sought to establish a set of self-assembling components that could be linked to observable 3D shapes by which the governing parameters of self-assembly could be disentangled and tractable. Recently, we discovered that artificial protein fragments (helical β-peptide foldamers) with well-defined hydrophobic surfaces self-assembled to form unprecedented 3D molecular architectures in a controlled manner in aqueous solution. We anticipate that our strategy can be a starting point for the rational design of 3D organic molecular architectures with various functions. Furthermore, the self-assembly behavior of artificial protein fragments will be relevant for the development of synthetic foldamer proteins.