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108th General Meeting of Korean Chemical Society New Advances in Metal-Mediated Alkylation and Fluoroalkylation Reactions

Submission Date :
8 / 29 / 2011 , 20 : 13 : 45
Abstract Number :
Presenting Type:
Presenting Area :
유기화학 - Recent Trends in Organic Chemistry
Authors :
David Vicic
University of Hawaii, United States
Assigned Code :
ORGN-3 Assigend Code Guideline
Presenting Time :
목 14시 : 40분

Here we present our efforts to understand at a fundamental level how transition-metals may better introduce alkyl and perfluoroalkyl groups into organic substrates. Such methods are needed as developmental pipelines for new drugs are predicted to contain an extraordinarily high percentage of fluorinated molecules. The trifluoromethyl group, in particular, is becoming a privileged group in medicinal chemistry yet many difficulties are associated with efficient ways to introduce this group into organic molecules. We report here that new copper and nickel complexes show promise for the development of catalytic methods of fluoroalkylation. New methods for the construction of C(alkyl)-C(alkyl) bonds are also of interest as we move “beyond the flatlands” in organic coupling reactions, and mechanistic details of these reactions will also be discussed.