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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Single-Walled Carbon Nanotube/Polymer Hybrids for Near-Infrared Fluorescent Detection of Biological Molecules

2012년 2월 16일 17시 01분 06초
MAT2-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 00분
재료화학 - Recent Trends in Materials Chemistry
저자 및
한양대학교 화학공학과, Korea
A major challenge in the synthesis of nanotube or nanowire sensors is imparting selective analyte binding through means other than covalent linkages which compromise electronic and optical properties. We functionalized single-walled carbon nanotubes (SWNT) with synthetic polymers or proteins in non-covalent manner to selectively recognize the specific targets such as reactive oxygen and nitrogen species (ROS and RNS). First, we designed the SWNT-dextran hybrid (SWNT-dex) for selective detection of nitric oxide (NO). NO caused the nIR fluorescence change of SWNT-dex, but other reactive nitrogen and oxygen species didn’t change its nIR fluorescence. Finally, SWNT-dex was successfully applied to in-vitro NO detection. Second, we designed the array of SWNT/collagen optical sensor for single molecule detection of hydrogen peroxide (H2O2) that activates signal transduction pathways during angiogenesis. We utilized the SWNT/collagen sensor array to measure the single molecule efflux of H2O2 from human umbilical vein endothelial cells (HUVEC) in response to angiogenic stimulation by vascular endothelial growth factor A (VEGF-A) or the inorganic pro-angiogenic factor, europium (III) hydroxide nanorods. We found that the production of H2O2 following VEGF stimulation was elevated outside of HUVEC, but not for stimulation via nanorods while increased generation was observed in the cytoplasm for both cases, suggesting two distinct signaling pathways.