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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Injectable hydrogels for therapeutic applications

2012년 2월 22일 13시 47분 41초
BIO2-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 11시 : 00분
생명화학 - Approaches of applied chemistry for translational research
저자 및
아주대학교 분자과학기술학과, Korea
Injectable hydrogels have been paid much attention as an injectable matrix for therapeutic applications due to easy applications based on minimally invasive technique. Such a system makes cells, drugs and bioactive molecules easily incorporated in situ by a simply syringe injection of their aqueous solutions at target sites. Various types of hydrogels formed in situ through physical or chemical cross-linking reaction were reported. Among these reactions, enzymatic reaction using peroxidase has received much attention to fabricate in situ cross-linkable hydrogels due to biocompatibility and good controllability of the reaction rate. This cross-linking system enable hydrogels not only to be formed under mild conditions for short time period but also to be strengthened due to chemical cross-link, which are major issue in the development of in situ forming hydrogels. In addition, their physico-chemical properties can be controlled easily by varying the concentrations of catalysts. In this study, various kinds of in situ forming hydrogels via a peroxidase-mediated cross-linking reaction were developed as injectable matrices. To investigate the usefulness of the hydrogels as injectable materials for therapeutic applications, in vitro and in vivo studies have been performed using various bioactive molecules, cells and animal models. Obtained results demonstrated that our enzyme-mediated injectable hydrogels are promising materials for therapeutic applications including tissue regeneration and drug delivery. Acknowledgements: This research was supported by grants from the Korea Science and Engineering Foundation, Ministry of Education, Science and Technology (MEST) (2011-0001805), and a National Research Foundation (NRF) grant funded by the Korea government (2010-0027776).