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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Dopamine Detection Using Poly(dopamine) Formation on Bare Indium-Tin Oxide Electrode in the Presence of the Ascorbic Acid

2012년 2월 22일 16시 26분 18초
ELEC.P-1294 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
김병권, 양해식1, 곽주현
KAIST 화학과, Korea
1부산대학교 화학과, Korea
Dopamine is neurotransmitters which is important and widely investigated for the several decades. A deficiency of dopamine is associated with some physiological problems such as Parkinsonism, schizophrenia, and HIV infection. Therefore, the determination of the dopamine concentration is essential for disease diagnosis and for the study of physiological mechanisms. Dopamine can be easily electrooxidized owing to its high electroactivity. However, its selective detection in actual biological matrixes is limited by interfering molecules such as ascorbic acid. To solve these kinds of problems, various kinds of modified electrodes were suggested. These kinds of modified electrodes were showed good performance, but needed specific treatments and materials. Indium?tin oxide (ITO) electrodes have been widely used in displays and solar cells due to their high levels of optical transparency and conductivity. ITO electrodes have also been used in electrochemical sensors in an effort to utilize their low and reproducible capacitive background currents. The low electrocatalytic activities of ITO electrodes are significantly increased after the modification of ITO electrodes with electrocatalytic materials. This change allows for facile discrimination between two states before and after the modification process. We present a sensitive electrochemical method capable of detecting dopamine in the presence of ascorbic acid. This method employs the spontaneous formation of electrocatalytic poly(dopamine) films on bare ITO electrodes in a solution of dopamine. The electrooxidation current of hydrazine is used for the determination of the dopamine concentration.