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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Preparation of Fluorescent Polymer Based Multifunctional Nanoparticles for Bioapplication

2012년 2월 23일 13시 33분 21초
BIO.P-700 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
한국생명공학연구원 바이오나노연구단, Korea
The advance in biomedical imaging rely on the development of naoprobes with low toxicity with high sensitivity, resolution, and photostability. Fluorescence polymers have received a great deal of interest due to their unique physical properties such as conductivity, electroluminescence. Preparation and characterization of fluorescence polymer/Fe3O4 hybrid nanoparticles coated by silica shell were exhibited in this study. Fe3O4 nanoparticles are extensively inquired for in vivo and in vitro biomedical applications, such as magnetic resonance imaging (MRI). Silica-based fluorescent and magnetic multifunctional nanocomposites have been widely researched in the last few years, because they have a great potential in biomedical applications as optical and magnetic imaging agents. The integration of newly synthesized fluorescent polymer, which is poly[di(2-methoxy-5-(2-3ethylhexyloxy))-2,7-(9,9-dioctylfluorene)](PDDF) and Fe3O4 formed the uniform core/shell nanoparticles coated with silica by reverse micelle method. The bioapplication of core/shell nanoparticles was investigated by the various evaluations such as optical property, and fluorescent and MRI imaging in HeLa cells. As well as they showed an excellent photostability compared to quantum dots or organic dyes, as good permeability and low toxicity in the cells. [1] Qing Zhang, Yongai Zhai, Fenggi Liu, Meng Yang, Ge Hao, European Polymer Journal 44 (2008), 3957-3962. [2] Jinyoung Jeong, Miyoung Cho, Yong Taik Lim, Nam Woong Song, and Bong Hyun Chung, Angew. Chem. Int. Ed. 48 (2009), 5296-5299.