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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Altering biomimetic metal Induced aggregation process of F127 block copolymer by phosphate modified mesoporous silica nanoparticles

2012년 2월 23일 15시 10분 45초
PHYS.P-511 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
남윤우, 유창수, 장미림, 조은범, 이동국
서울과학기술대학교 정밀화학과, Korea
Amphiphilic block copolymers composed of hydrophilic poly (ethylene oxide)(PEO) and hydrophobic poly(propylene oxide)(PPO), including (Pluronic?) F-127 (EO99PO65EO99), have been applied in diverse areas such as environment, biomaterials and pharmaceutic[1~3]. The block copolymers are known to form different types of aggregates depending on conditions. Interestingly, the aggregations can be biomimetic. This biomimetic aggregation cab be used as a model to understand the aggregating process of biological molecules causing Alzheimer’s disease(AD) and Type II diabetes(MD2) [4~6]. Mesoporous silica nanoparticles (MSNs) have been intensively studied due to several attractive features, such as large surface areas and easy surface functionalization [7~9]. In this study, we have synthesized phosphate modified mesoporous silica nanoparticles(PMSNs) and investigated the effect of these nanoparticles on the biomimetic metal induced aggregation process of block copolymer F-127 using biophysical means such as 1H-NMR, DSC, ITC, UV-VIS and TEM. This biomimetic system is to mimic peptide oligomerization process accelerated by metal ion, which is believed to be crucial in amyloidosis such as Alzheimer’s disease(AD) and Type II diabetes(MD2). P-MSNs show the capability of altering the intrinsic aggregation pathway of F-127 induced by Mn2+ ions. This effect is thought to be mediated by strong electrostatic attraction force between negatively charged phosphate functional group of PMSN and positively charged Mn2+ ion. Results suggest that PMSNs could alter the biomimetic metal induced aggregation process of F127 block copolymer. [1] K. Huang, B.P. Lee, D.R. Ingram, P.B. Messersmith, Biomacromolecules. 2002, 3, 397-406. [2] K.H. Bae, Y.H. Lee, T.G. Park, Biomacromolecules. 2007, 8, 650?656. [3] T.K. Jain, M.A. Morales, S.K. Sahoo, D.L. Leslie-Pelecky, V. Labhasetwar, Mol. Pharmaceutics. 2005, 2, 194?205. [4] F. Ahmed, P. Alexandridis, S. Neelamegham, Langmuir. 2001, 17, 537-546. [5] J. Yuan, Z. Xu, S. Cheng, L. Feng, Eur. Polym. J. 2002, 38, 1537-1546. [6] C. M. Jan, V. Hest, J. Mac. Sci. 2007, 47, 63-92. [7] V.J. Mohanraj, Y. Chen, Trop. J. Pharm. Res. 2006, 5, 561-573. [8] I.I. Slowing, J.L. Vivero-Escoto, C.W. Wu, V.S.Y. Lin, Advanced Drug Delivery Reviews. 2008, 60, 1278?1288. [9] I.I. Slowing, B.G. Trewyn, V.S.Y. Lin, J. Am. Chem. Soc. 2007, 129, 8845-8849.