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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Efficient siRNA delivery in vitro and in vivo using mesoporous silica nanoparticles with large pores

2012년 2월 23일 18시 11분 29초
MAT.P-1205 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
나희경, 민달희1
KAIST 화학과, Korea
1서울대학교 화학과, Korea
RNA interference (RNAi) is an evolutionarily conserved biological process in which a double stranded RNA inhibits gene expression by degrading target mRNA or by blocking the translation pathway of a specific gene. The application of RNAi using siRNA (small interfering RNA) in biomedical area might have great potential to treat diseases that cannot be treated by conventional small molecule drug. Mesoporous silica materials appear to possess immense potentials in catalysis, biosensors and drug delivery systems due to their tunable pore and particle size, high surface area, large pore volume, and biocompatibility. In particular, monodispersed silica spheres with large pores are very important for the incorporation of large molecules such as metal complexes and proteins into mesopores, and for the retention of pore space after grafting of organic functional groups. Here, we report an efficient siRNA delivery system based on pore expanded silica nanoparticle. It is shown that newly developed siRNA delivery system is novel and powerful gene delivery vehicle in vitro and in vivo. Our study demonstrates that siRNA-pore expanded silica nanoparticle complex can serve as potential gene silencing therapeutics for treating various diseases.