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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and characterization of Silica microbeads incorporated with water-soluble Quantum dots for ultrasensitive DNA sensor applications

2012년 2월 29일 18시 48분 43초
MAT.P-1212 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
이지혜, 구은회1
고려대학교, Korea
1한국세라믹기술원 바이오IT융합, Korea
Ultrasensitive DNA detection is necessary in clinical diagnostics, gene analysis, and a variety field of biomedical studies. In microarray gene analysis, signal amplification is the most critical issue and is typically achieved by fluorophores, such as organic dyes to the DNA probes. Semiconductor Quantum dots (QDs) have novel optical properties such as simultaneous excitation, size-tunable emission, high stability against photobleaching and narrow, symmetrical emission peak. Silica microbeads incorporated with QDs have several advantages compared with organic dyes in bioanalysis array system. First, large number of QDs are encoded a single micro beads, which produces a strong fluorescence signal when it is excited properly. Second, the microbead is highly photostable, when they are inside the silica network. Third, the silica surface is easily modified as a biocompatible and versatile substrate for the immobilization of biomolecules. In this study, we have investigated the silica microbeads incorporated with water-soluble QDs and modified silica microbeads surface for applied more usefully to biological systems. Furthermore, the microstructure, optical properties and the sensitivity of the microbeads incorporating with water-soluble QDs were characterized by transmission electron microscopy, scanning electron microscopy, Fluorescence microscopy, UV-Vis spectroscopy, respectively.