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114th General Meeting of Korean Chemical Society Synthesis of Bassiamide from Cordyceps Bassiana

Submission Date :
8 / 28 / 2014 , 16 : 19 : 08
Abstract Number :
Presenting Type:
Poster Presentation
Presenting Area :
Authors :
김기현, 이윤미*
광운대학교 화학과, Korea
Assigned Code :
ORGN.P-866 Assigend Code Guideline
Presenting Time :
10월 15일 (수요일) 16:00~19:00
The bassiamide, a novel natural product, was recently isolated from Cordyceps bassiana, which is one of the most important species in traditional Chinese medicine. In order to examine the biological activities such as anti-cancer, anti-inflammatory, and antiviral, we envisioned the synthesis of bassiamide started from 2-hydroxymethyl-1,3-propanediol. Our synthesis involves three key transformations such as the dialkylation of dimethyl malonate, the HWE olefination for the synthesis of an amide intermediate, and N-monoalkylation.