초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Three-Membered Rings and Triple Bonds as Ideal Starting Materials for Domino Cascades

2014년 9월 1일 19시 29분 52초
ORGN2-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 10분
유기화학 - Current Trends in Organic Chemistry II: Metallo-Organic Reaction
저자 및
Daniel B. Werz
Technische Universität Braunschweig, Germany, Germany
※ 국외소속으로 등록된 저자의 승인여부는 최소 3일이내 발표자 email로 알려드립니다.
승인 1건

Cyclopropanes as well as carbon-carbon triple bonds are systems being high in energy. Therefore, both moieties are ideally suited for a cascade of consecutive reactions (domino reactions). In a first part, domino reactions based on ring-enlargement reactions of donor-acceptor-substituted cyclopropanes are discussed. Aldehyde, ketimines and thioketones are utilized as acceptors whereas ether moieties serve as donor. A rearrangement leads to the respective five-membered rings which tend to eliminate water. As a result, aromatic systems are formed. Depending on the substrate domino cascades are initiated which are able to transform the biscyclopropane derivative 1 in one step into the corresponding quaterpyrrol 2. In a second part, Pd-catalyzed domino reactions starting with triple bonds attached to carbohydrate derivatives 4 are reported to construct a variety of chroman- and isochroman-type structures such as 5. Such domino sequences are also employed to a variety of other processes leading to complex scaffolds in a facile and efficient fashion.