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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of the fluorescent probe for the imaging of β-amyloid plaques : Catechol derivative

2014년 9월 3일 17시 33분 10초
MEDI.P-976 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 15일 (수요일) 16:00~19:00
저자 및
정승진, 이준영1, 김보람2, 이상윤1, 박정훈2, 허민구2, 양승대2, 박용대2,*
한국원자력연구소 방사선 기기연구부 (정읍), Korea
1동국대학교 신소재화학과, Korea
2한국원자력연구원 방사선기기연구부, Korea
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by deposition of mis-folded β-amyloid (Aβ) peptides as senile plaques in the brain. Because the deposition of Aβ plaques is an early event in the development of AD, a validated biomarker of Aβ deposition in the brain might prove useful to identify and to assist in the evaluation of new anti-amyloid therapies currently under development. Fluorescent probes that can stain Aβ plaques have gained increasing interest as potential tools for monitoring the progression of AD. In this study, fluorescent probe contained catechol ring for the Aβ plaques was developed and evaluated the optical properties for Aβ peptides. The developed catechol probe exhibited an approximately 34-fold increase in emission intensity after mixing with Aβ peptide, a high affinity for Aβ peptide (KD = 0.35 ?M),and the reasonable hydrophobic property (logP = 2.94) to penetrate the blood barrier brain. We also confirmed our catechol probe specifically stained Aβ plaques in the histological costaining using transgenic mice (APP/PS1) brain sections. Our catechol probe showed a possibility to be fluorescent probe for detecting Aβ plaques in the brain from AD.