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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Graphite surface assisted laser desorption ionization time-of-flight mass spectrometry for small organic molecules

2016년 9월 1일 14시 33분 39초
ANAL.P-70 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 14일 (금요일) 11:00~12:30
저자 및
김민선, 서정주, 김정환*
한국기초과학지원연구원 질량분석장비개발팀, Korea
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI TOF MS) has been proven as a particularly fast and effective tool for not only for the analysis of large molecules such as proteins and polymers but also for determination of small organic molecules. However, the detection of small organic molecules in MALDI TOF MS is screened by the common matrices and the inhomogeneous sample preparation is still remained one of major difficulties. Thus, matrix-free mass spectrometric techniques such surface-assisted laser desorption ionization mass spectrometry(SALDI) offer significant advantages for the analysis of small organic molecules.[1] Graphite plate is effective not only as an energy transfer medium like as a MALDI matrix but also as a sample substrate.[2,3] On graphite plate which has a hydrophobic surface property, sample preparation for hydrophobic materials is relatively easy and convenience to form homogenous sample surface, whereas hydrophilic materials such as amino acid and small peptide. In this study, we are demonstrated the SALDI TOF MS for small organic molecules using graphite plate as a sample substrate. Moreover, the sample preparation method for the hydrophilic materials is examined. The variety of application of graphite SALDI TOF MS will be discussed in detail. [1] Dattelbaum AM and Iyer S.,Expert Rev Proteomics., 2006, 3(1), pp. 153-61. [2] Junghwan Kim and Weekyung Kang., Bull. Kor. Chem. Soc., 2000, 21, pp. 401-404 [3] Kim and et. al., Bull. Kor. Chem. Soc., 2002, 23, pp. 315-319